Top 10 Safest Companies To Watch For 2014

Despite turmoil in Washington and skepticism over the Affordable Care Act, two industry heavyweights remain bullish about equities and the economy.

“Forecasting the market is pretty basic — just watch the correlation to corporate earnings growth and the S&P 500,” Douglas Cot� the chief investment strategist at ING U.S. Investment Management, told an audience of over 500 at the Investment Management Consultants Association's Advanced Wealth Management Conference in Chicago. “When earnings grow, stocks go up and when earnings slow stocks go down.”

With that in mind, and in the context of what he described as “the Washington mess,” Mr. Cot�said the “safest trade right now is to get back to a full allocation to equities.”

Top Semiconductor Companies To Watch For 2015: Red Lion Hotels Corporation(RLH)

Red Lion Hotels Corporation, a hospitality and leisure company, engages in the ownership, operation, and franchising of midscale, full, select, and limited service hotels under the Red Lion brand. As of June 30, 2011, its hotel network comprised of 44 hotels located in 8 states and 1 Canadian province, with 8,457 rooms. The company also offers ticketing services and promotion and presentation of entertainment productions, as well as provides ticketing inventory management systems, call center services, and outlet/electronic channel distribution for event locations. In addition, it has direct ownership interest in a retail mall in Kalispell, Montana, as well as involves in the real estate investments. The company was formerly known as WestCoast Hospitality Corporation and changed its name to Red Lion Hotels Corporation in September 2005. Red Lion Hotels Corporation was founded in 1937 and is based in Spokane, Washington.

Advisors' Opinion:

• [By Laura Brodbeck]

  Monday

  Earnings Releases Expected: Sotheby�� (NYSE: BID), Otelco (NASDAQ: OTEL), Rackspace Hosting, Inc. (NYSE: RAX), Red Lion Hotels Corporation (NYSE: RLH) Economic Releases Expected: Italian industrial production, Mexican industrial production, Portuguese trade balance

  Tuesday

Top 10 Safest Companies To Watch For 2014: Acasti Pharma Inc (ACST)

Acasti Pharma Inc. (Acasti) is engaged in developing a product portfolio of long-chain omega-3 phospholipids. Acasti is a majority owned subsidiary of Neptune Technologies and Bioressources Inc. (Neptune). The Company has one operating segment: the development and commercialization of pharmaceutical applications of its licensed rights for cardiovascular diseases. The Company�� product portfolio includes concentrated phospholipids which functionalize eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Acasti is the producer of anti-dyslipidemic prescription drugs (CaPre), medical foods (Onemia) and over-the-counter (OTC) products (Vectos). During the fiscal year ended February 28, 2011 (fiscal 2011), the Company has completed the development and launched medical food, Onemia. Advisors' Opinion:

• [By James E. Brumley]

  What do Acasti Pharma Inc. (NASDAQ:ACST), Kandi Technologies Group Inc. (NASDAQ:KNDI), and Amarantus Bioscience Holdings, Inc. (OTCBB:AMBS) have in common? Not a lot, if you're simply looking at their business lines. Kandi Technologies Group makes electric cars, and even though Amarantus Bioscience Holdings and Acasti Pharma are both in the pharmaceutical arena, they're not too much alike. There is one common element among AMBS, ACST, and KNDI right now, however... they're three of the market's most bullish setups. Anyone looking for a new trading idea here should start with one of these three.

Top 10 Safest Companies To Watch For 2014: Aqua America Inc.(WTR)

Aqua America, Inc., through its subsidiaries, operates regulated utilities that provide water or wastewater services in the United States. The company serves residential, commercial, fire protection, industrial, and other water and wastewater customers in Pennsylvania, Texas, North Carolina, Ohio, Illinois, New Jersey, New York, Florida, Indiana, Virginia, Maine, Missouri, and Georgia. It also provides water and wastewater services through operating and maintenance contracts with municipal authorities and other parties, as well as sludge hauling, septage and grease services, and backflow prevention services. The company was formerly known as Philadelphia Suburban Corporation and changed its name to Aqua America, Inc. in 2004. Aqua America, Inc. was founded in 1968 and is based in Bryn Mawr, Pennsylvania.

Advisors' Opinion:

• [By David Dittman]

  Question: Thanks for your input and the chat opportunity! Your long term thoughts on water stocks such as Companhia de Saneamento Basico do Estado de Sao Paulo (NYSE: SBS), known popularly as Sabesp, and Consolidated Water Co Ltd (NSDQ: CWCO)? I hold Aqua America Inc (NYSE: WTR) since your recommendation.

• [By David Dittman]

  Answer: Our favorite water utilities–American Water Works, Aqua America Inc (NYSE: WTR), Connecticut Water Service Inc (NSDQ: CTWS)–are solid dividend growers throughout the cycle, and they all have pretty good growth prospects because of the abundance of small-scale municipal water utilities in their footprints.

• [By Sean Williams]

  The first big risk for American Water Works and the water utility sector as a whole is the need for infrastructure and maintenance upgrades. The downside of expanding into new territories and picking up new customers is that pipe, sewer, and storage tank maintenance is needed just to keep operations running. American Water Works' primary rival, Aqua America (NYSE: WTR  ) , spent $1.4 billion in maintenance and upgrades alone between 2007 and 2011. American Water Works, by contrast, will spend $950 million just in 2013 for maintenance and upgrades. These costs are already painful to begin with, but when capex costs are unexpected it can negatively impact a water utility's bottom line.

• [By Vita Nelson]

  Our latest featured dividend reinvestment idea is Aqua America (WTR). Founded in 1968, and headquartered in Bryn Mawr, Pennsylvania, Aqua America operates regulated utilities that provide water or wastewater services in the United States.

Top 10 Safest Companies To Watch For 2014: Anglo American PLC (AAUKY.PK)

Anglo American plc (Anglo American), incorporated on May 14, 1998, is a mining company. The Company�� portfolio include Bulk commodities which consists of iron and manganese, metallurgical coal and thermal; base metals, which consists of copper, nickel and niobium; Precious metals and minerals, which include platinum and diamonds and Other Mining and Industrial. The Company operates in Africa, Brazil, Chile, North and South America, Australia, China, India, Japan, other Asia and Europe. In November 2013, Anglo American PLC announced the completion of its sale of the Amapa iron ore operation in Brazil (Amapa) to Zamin Ferrous Ltd. In January 2014, Anglo American completed the acquisition of Mineral Technology Exploration Production SA (MINTEP) and Societe Miniere d'Alumine SA.

Iron and Manganese

The Company�� Iron Ore portfolio consist a 69.7% holding in Kumba Iron Ore Limited (Kumba), a supplier of seaborne iron ore, and Iron Ore Brazil�� 100% interest in Anglo Ferrous Minas-Rio, a 49% shareholding in LLX Minas-Rio, which owns the port of Acu, and a 70% interest in the Amapa iron ore system. During the year ended December 31, 2012, Kumba operated three mines: Sishen Mine in the Northern Cape, which produced 33.7 million tons (MT) of iron ore, Thabazimbi Mine in Limpopo, with an output of 0.8 MT and Kolomela mine, also in the Northern Cape and produced 1.5 MT. During 2011, Kumba exported more than 85% of its total iron ore sales volumes of 44.4 million tons, with 69% of these exports destined for the People�� Republic of China and the remainder to Europe, Japan, South Korea and the Middle East. Its Minas-Rio iron ore project is located in the states of Minas Gerais and Rio de Janeiro.

The Company�� Manganese interests consist of a 40% holding in Samancor Holdings, which owns Hotazel Manganese Mines and Metalloys, both in South Africa, and a 40% holding in each of the Australian-based operations Groote Eylandt Mining Company (GEMCO) and Tasmanian Electro ! Metallurgical Company (TEMCO), with BHP Billiton owning 60% and having management control. It is producer of seaborne manganese ore and is top three global producers of manganese alloy. Its operations produce a combination of ores, alloys and metal from sites in South Africa and Australia.

Metallurgical Coal

The Company�� coal operations in Australia are based on the east coast, from where Metallurgical Coal serves a range of customers throughout Asia and the Indian subcontinent, and Europe and South America. Its metallurgical coal operation in Canada, Peace River Coal, mainly serves customers in Europe, Japan and South America. Metallurgical Coal operated six mines, one wholly owned and five in which it has a controlling interest. Five of the mines are located in Queensland�� Bowen Basin: Moranbah North (metallurgical coal), Capcoal (metallurgical and thermal coal), Foxleigh (metallurgical coal), Dawson (metallurgical and thermal coal) and Callide (thermal coal). Drayton mine (thermal coal) is in the Hunter Valley in New South Wales. Moranbah North is an underground longwall mining operation with a mining lease covering 100 square kilometers.

Capcoal operates two longwall underground mines and an open cut mine. Together, they produce around 5.0 MT annually of hard coking coal, pulverised coal injection (PCI) and thermal coal. Capcoal also supplies methane-rich seam gas to Energy Developments Limited�� power station. Foxleigh is an open cut operation with an annual output exceeding 1.4 million tons of PCI coal. During 2012, Dawson, which is an open cut operation, produced 4.6 MT total of coking and thermal coal. During 2012, Capcoal operates two underground mines and an open cut mine. Together, they produced around 6.0 Mt of hard coking, pulverised coal injection (PCI) and thermal coals. During 2012, Foxleigh is an open cut operation which produced 1.9 Mt of high quality PCI coal.

Thermal Coal

Thermal Coal operates in South Africa a! nd and is! a joint partner in Cerrejon, Colombia. In South Africa, Thermal Coal wholly owns and operates nine mines and has a 50% interest in the Mafube colliery and Phola washing plant. During 2012, six of the mines supplied 23 million tons per annum of thermal coal to both export and local markets. New Vaal, New Denmark and Kriel collieries are domestic product operations supplying 29 million tons per annum of thermal coal to Eskom, the state-owned power utility. During 2012, Isibonelo mine produced five million tons per annum of thermal coal for Sasol Synthetic Fuels, the coal to liquids producer, under a 20 year supply contract. Thermal Coal�� South African operations route all export thermal coal through the Richards Bay Coal Terminal (RBCT), in which it has a 24.2% shareholding, to customers throughout the Med-Atlantic and Asia-Pacific regions. Within South Africa, 62% of total sales tons are made to the Eskom power utility.

Copper

The Company has interests in six copper operations in Chile. The wholly owned operations consists of the Mantos Blancos and Mantoverde mines, and it hold a 50.1% interest in Anglo American Sur (AA Sur), which includes the Los Bronces and El Soldado mines and the Chagres smelter. It has a 44% interest in the Collahuasi mine. The mines also produce associated by-products, such as molybdenum and silver. In addition, it has interests in Quellaveco and Michiquillay projects in Peru and a 50% interest in the Pebble project in Alaska.

Nickel

Nickel has three ferronickel operations: Codemin and Barro Alto in Brazil and Loma de Niquel in Venezuela. Within the

business unit�� portfolio there are also two projects, Jacare and Morro Sem Bone, both in Brazil, and exploration projects in Finland, Canada and Australia.

Platinum

The Company�� Platinum business, based in South Africa, is the producer of platinum. Platinum mines, processes and refines the entire range of platinum group metals (PGMs): platin! um, palla! dium, rhodium, ruthenium, iridium and osmium. Base metals such as nickel, copper and cobalt sulphate are secondary products and are contributors to earnings. Platinum�� operations exploit reserve of PGMs, known as the Bushveld Complex, which contains PGMbearing Merensky, UG2 and Platreef ores. During the year ended December 31, 2012, Platinum wholly owns 10 mining operations in production, a tailings re-treatment facility, three smelters, a base metals refinery and a precious metals refinery. Concentrating, smelting and refining of the output are undertaken at Rustenburg Platinum Mines��(RPM) metallurgical facilities. During 2012, Platinum�� 100% owned mining operations consists of the five mines at Rustenburg Section: Khomanani, Bathopele, Siphumelele, Thembelani and Khuseleka; Amandelbult Section�� two mines, Tumela and Dishaba, as well as Mogalakwena and Twickenham mines. Union Mine is 85% held with a black economic empowerment (BEE) partner, the Bakgatla-Ba-Kgafela traditional community, holding the remainder. The Unki mine in Zimbabwe is wholly owned.

Diamonds

The Company�� diamond interests are represented by its 40% holding in De Beers. The other shareholders in De Beers are Central Holdings Ltd, which owns 40%, and the Government of the Republic of Botswana (GRB) with 15%. De Beers is a diamond company producing diamonds from its mines in Botswana, Canada, Namibia and South Africa. As of December 31, 2012, De Beers held a 50% interest in Debswana Diamond Company and in Namdeb Diamond Corporation. In addition, De Beers has a 74% holding in South African based De Beers Mines Limited. De%Beers owns 100% of De%Beers Canada. De%Beers owns 100% of The Diamond Trading Company (DTC). De Beers, through Element Six Technologies, is a supplier of industrial supermaterials. Element Six operates internationally, with 10 manufacturing sites globally and a global sales network.

Advisors' Opinion:

• [By Ben Kramer-Miller]

  The Pebble Project is an enormous potential mine in Alaska containing mostly copper, and some gold and molybdenum. The project is owned by the Pebble Partnership, of which Northern Dynasty Minerals owns half, while Anglo American (AAUKY.PK) owns the other half.

Top 10 Safest Companies To Watch For 2014: Legg Mason Inc (LM)

Legg Mason, Inc. (Legg Mason), incorporated in 1981, is a global asset management company. The Company, through its subsidiaries, provides investment management and related services to institutional and individual clients, company-sponsored mutual funds and other pooled investment vehicles. It offers these products and services directly and through various financial intermediaries. The Company provides its asset management services through a number of asset managers, each of which generally markets its products and services under its own brand name and, in many cases, distributes retail products and services through a centralized retail distribution network. Its investment advisory services include discretionary and non-discretionary management of separate investment accounts in a number of investment styles for institutional and individual investors. Legg Mason�� investment products include mutual funds ranging from money market and other liquidity products to fixed income and equity funds managed in a variety of investment styles, other domestic and offshore funds offered to both retail and institutional investors and funds-of-hedge funds. As of March 31, 2012, assets under management were $643.3 billion. During the fiscal year ended March 31, 2012 (fiscal 2012), the Company sold Bartlett & Co., a Cincinnati-based wealth manager.

Asset Managers

The Company conducts its business primarily through 12 asset managers. Its asset managers are individual businesses, each of which generally focuses on a portion of the asset management industry in terms of the types of assets managed (primarily equity or fixed income), the types of products and services offered, the investment styles utilized, the distribution channels used, and the types and geographic locations of its clients. The Company�� asset managers provide a range of separate account investment management services to institutional clients, including pension and other retirement plans, corporations, insurance companies, ! endowments and foundations and governments, and to high-net-worth individuals and families. In addition, its asset managers also sponsor and manage various groups of the United States mutual funds, including the Legg Mason Funds, The Royce Funds and the Western Asset Funds, funds-of-hedge funds and a number of equity, fixed income, liquidity and balanced funds that are domiciled and distributed in countries worldwide, and provide investment advisory services to a number of retail separately managed account programs. Western Asset Management Company is a global fixed income asset manager for institutional clients. Western Asset's operations include investment operations in New York City, the United Kingdom, Japan, Brazil, Australia and Singapore. Western Asset offers a range of products spanning the yield curve and encompassing the bond markets, including a suite of limited duration and core products, emerging market and high yield portfolios, municipal portfolios and a variety of sector-oriented and global products. Among the services Western Asset provides are management of separate accounts and management of mutual funds, closed-end funds, international funds and other structured investment products.

ClearBridge Advisors is an equity asset management firm. ClearBridge Advisors provides asset management services to 29 of the equity funds (including balanced funds and closed-end funds) in the Legg Mason Funds, to retail separately managed account programs, to certain of its international funds and, primarily through separate accounts, to institutional clients. ClearBridge also sub-advises domestic mutual funds that are sponsored by third parties. Royce & Associates is investment advisor to all of The Royce Funds and to certain of the Company�� international funds. In addition, Royce & Associates manages other pooled and separate accounts, primarily institutional. Brandywine Global Investment Management manages fixed income, including global and international fixed income, and equity portf! olios for! institutional and, through wrap accounts, high-net-worth individual clients.

Batterymarch Financial Management manages the United States, international and emerging markets equity portfolios for institutional clients. Permal Group Ltd. is a global funds-of-hedge funds management firm. With a headquarters in London and other offices in New York City, Boston, Dubai, Paris, Tokyo, Hong Kong, Singapore and Nassau, Permal manages products, which include both directional and absolute return strategies, and are available through multi-manager and single manager funds, separately managed accounts and structured products sponsored by a number of financial institutions. Legg Mason Capital Management is an equity asset management business that manages both institutional separate accounts and mutual funds. Legg Mason Capital Management manages 12 Legg Mason Funds, and also sub-advises the mutual fund managed by the joint venture described below and investment products sponsored by its other subsidiaries, including certain of the Company�� international funds.

Legg Mason Investment Counsel & Trust Company, National Association is a national banking association with authority to exercise trust powers. Legg Mason Investment Counsel & Trust Company provides services as a trustee for trusts established by its individual and employee benefit plan clients and manages fixed income and equity assets. Legg Mason Investment Counsel, LLC, a subsidiary of Legg Mason Investment Counsel & Trust, manages equity, fixed income and balanced portfolios for high-net-worth individual and institutional clients and a number of its mutual funds. Legg Mason Investment Counsel operates out of offices in New York City, Cincinnati, Philadelphia, Easton, Maryland, and Bryn Mawr, Pennsylvania. Esemplia Emerging Markets is an emerging markets equities investment manager. Esemplia offers a range of portfolio management strategies, including core long-only and alpha-extension portfolios, to institutional investors worl! dwide, in! cluding pension funds and sovereign wealth funds.

Private Capital Management manages equity assets for high-net-worth individuals and families, institutions, endowments and foundations in separate accounts and through limited partnerships. Legg Mason's business in Poland engages in portfolio management, servicing and distribution of both separate account management services and local funds in Poland. The firm provides portfolio management services primarily for equity assets to institutions, including corporate pension plans and insurance companies, and, through funds distributed through banks and insurance companies, individual investors. Legg Mason Australian Equities is an Australian asset management business that offers Australian equity products, Australian property trusts and asset allocation products. As of March 31, 2012, Legg Mason Australian Equities managed assets with a value of $1billion.

United States Mutual Funds

The Company�� United States mutual funds business primarily consists of three groups of mutual and closed-end funds, the Legg Mason Funds, The Royce Funds and the Western Asset Funds. The Legg Mason Funds invest in a range of domestic and international equity and fixed income securities. The Royce Funds invest primarily in smaller-cap company stocks using a value investment approach. The Western Asset Funds invest primarily in fixed income securities. The Legg Mason Funds consist of 113 mutual funds and 27 closed-end funds in the United States, almost all of which are sub-advised by its subsidiary asset managers. The mutual funds and closed-end funds within the Legg Mason Funds include 63 equity funds (including balanced funds) that invest in a spectrum of equity securities. The fixed income and liquidity mutual funds and closed-end funds within the Legg Mason Funds include 77 funds. As of March 31, 2012 , the Legg Mason Funds included $114.7 billion in assets, respectively, in their mutual funds and closed-end funds, of which approximate! ly 30% an! d 27%, respectively, were equity assets, approximately 24% and 18%, respectively, were fixed income assets and approximately 46% and 55%, respectively, were liquidity assets.

The Royce Funds consist of 32 mutual funds and three closed-end funds, most of which invest primarily in smaller-cap company stocks. The Royce Funds are distributed through non-affiliated fund supermarkets, its centralized funds distribution operations, non-affiliated wrap programs, and direct distribution. In addition, two of the portfolios in The Royce Funds are distributed only through insurance companies. The Company�� mutual funds business also includes the Western Asset Funds, a family of nine mutual funds and two closed-end funds. The mutual funds are marketed primarily to institutional investors and retirement plans through the Company�� institutional funds marketing group. Western Asset Management Company manages these funds. The funds primarily invest in fixed income securities.

International Funds

The Company, outside the United States, manages, supports and distributes a number of funds across an array of global fixed income, liquidity and equity investment strategies. Its international funds include a range of cross border funds that are domiciled in Ireland and Luxembourg and are sold in a number of countries across Asia, Europe and Latin America. The Company�� international funds also include local fund ranges that are available for distribution in the United Kingdom, Australia, Japan, Singapore, Poland, Hong Kong and Canada. All of its international funds are distributed and serviced by Legg Mason's global distribution group. Its international funds include equity, fixed income, liquidity and balanced funds that are primarily managed or sub-advised by Batterymarch Financial Management, Brandywine Global, ClearBridge, Esemplia, Legg Mason Capital Management, Private Capital Management, Royce & Associates, Western Asset Management and its global asset allocation team. In a! ggregate,! the Company sponsors and manages more than 220 of these international funds.

Retail Separately Managed Account Programs

The Company is a provider of asset management services to retail separately managed account programs, commonly known as managed account or wrap programs. These programs typically allow securities brokers or other financial intermediaries to offer their clients the opportunity to choose from a number of asset management services. It provides investment management services to a number of retail separately managed account programs sponsored by a number of financial institutions.

Distribution

The Company�� centralized global distribution group distributes and supports its United States and international funds and retail separately managed account program business. The United States-based operations of the Company�� global distribution group support and distribute the Legg Mason Funds, The Royce Funds and the Western Asset Funds, and include its mutual fund wholesalers and its institutional funds marketing group. The Company�� mutual fund wholesalers distribute the Legg Mason Funds through a number of third-party distributors. The Company�� institutional funds marketing group distributes institutional share classes of the Legg Mason Funds and the Western Asset Funds to institutional clients and also distributes variable annuity sub-advisory services provided by its asset managers to insurance companies. Its institutional liquidity funds are primarily distributed by Western Asset's distributors. In addition to its centralized funds distribution group, Royce & Associates' distributors also distribute The Royce Funds. In addition to distributing funds, the wholesalers in the Company�� global distribution operations also support its retail separately managed account program services. These services are provided through programs sponsored by Morgan Stanley Smith Barney's retail business, as well as other financial institutions.

! The international distributors within the Company�� global distribution group offer its investment management services to individual and institutional investors across Asia, Europe and the Americas. These distributors operate out of distribution offices in 18 cities in 14 countries and are the sole distributors of its cross border funds globally and its international local funds in their respective countries. Legg Mason Investments is responsible for the distribution and servicing of cross border and local fund ranges across Europe, the Americas and Asia. Legg Mason Investments has offices in locations including London, Paris, Milan, Geneva, Frankfurt, Madrid, Singapore, Hong Kong, Taipei, Miami, Santiago and New York. In addition to Legg Mason Investments, the Company�� global distribution group includes separate distribution operations in Australia, Canada and Japan. In Australia, its distribution operations distribute local and cross border pooled investment vehicles sub-advised by the Company�� asset managers primarily to retail investors, pension plans, fund-of-funds managers, insurance companies and government funds/agencies. In Canada, its distribution operations distribute Legg Mason-managed products primarily to pension plans, endowments, foundations, banks and mutual fund companies and separately managed account programs. In Japan, the Company�� distribution operations distribute domestic investment funds, cross border funds and institutional separate accounts primarily to the retail market, which includes retail banks, private banks, asset managers, funds platforms and insurance companies.

Advisors' Opinion:

• [By MONEYMORNING.COM]

  So it's no surprise that on Thursday, none other than Bill Miller, the Chairman and CEO of Legg Mason Inc. (NYSE: LM) subsidiary LMM, told Bloomberg Television that "Bitcoin is like making a venture bet. The potential return is huge."

• [By Shauna O'Brien]

  On Wednesday, asset management firm Legg Mason Inc (LM) reported that its assets under management declined 1.8% in August due to unfavorable markets and outflows.

  Total preliminary assets under management fell to $645 billion in August, down from July due to unfavorable markets and outlooks in both equity and fixed income. August equity assets under management reflect a $1.3 billion disposition of a non-core affiliate.

  Legg Mason shares were mostly flat during pre-market trading Wednesday. The stock is up 36% YTD.

Top 10 Safest Companies To Watch For 2014: BioCryst Pharmaceuticals Inc.(BCRX)

BioCryst Pharmaceuticals, Inc., a biotechnology company, designs, optimizes, and develops small-molecule pharmaceuticals that block key enzymes involved in infectious diseases, cancer, and inflammatory diseases. It uses structure-based drug design, which incorporates multiple scientific disciplines, including biology, crystallography, medicinal chemistry, and computer to develop new therapeutic candidates. The company has three novel late-stage compounds in development, which include Peramivir, a neuraminidase inhibitor for the potential treatment of influenza; BCX4208, a purine nucleoside phosphorylase (PNP) inhibitor for gout; and Forodesine, a PNP inhibitor for cutaneous T-cell lymphoma (CTCL) and chronic lymphocytic leukemia (CLL). Peramivir is being developed under a contract from the Biomedical Advanced Research and Development Authority within the United States Department of Health and Human Services. Forodesine has been granted orphan drug status by the FDA for thr ee indications, which include T-cell non-Hodgkin?s lymphoma, including CTCL; CLL and related leukemias, including T-cell prolymphocytic leukemia, adult T-cell leukemia, and hairy cell leukemia; and for treatment of B-ALL. The FDA has also granted fast track status to the development of forodesine for the treatment of relapsed or refractory T-cell leukemia, and special protocol assessment from the FDA for forodesine to conduct a pivotal clinical trial in CTCL with an oral formulation. The company announced the initiation of a Phase 2b study of BCX4208 as add-on therapy in gout patients who have not responded to allopurinol therapy alone. BioCryst Pharmaceuticals utilizes crystallography and structure-based drug design to discover additional compounds and to progress others through pre-clinical and early development to address the unmet medical needs of patients and physicians. The company was founded in 1986 and is headquartered in Durham, North Carolina.

Advisors' Opinion:

• [By Jon C. Ogg]

  BioCryst�Pharmaceuticals Inc. (NASDAQ: BCRX) was started as Outperform with a $7 to $9 price target range at Wells Fargo.

  Canadian Pacific Railway Ltd. (NYSE: CP) was upgraded to Outperform from Neutral and the price target was raised to $144 from $139 at Credit Suisse.

Top 10 Safest Companies To Watch For 2014: Royal Dutch Shell PLC (RDSA)

Royal Dutch Shell plc (Shell), incorporated on February 5, 2002, is an independent oil and gas company. The Company owns, directly or indirectly, investments in the numerous companies constituting Shell. Shell is engaged worldwide in the principal aspects of the oil and gas industry and also has interests in chemicals and other energy-related businesses. The Company operates in three segments: Upstream, Downstream and Corporate. Upstream combines the operating segments Upstream International and Upstream Americas, which are engaged in searching for and recovering crude oil and natural gas; the liquefaction and transportation of gas; the extraction of bitumen from oil sands that is converted into synthetic crude oil, and wind energy. Downstream is engaged in manufacturing; distribution and marketing activities for oil products and chemicals, in alternative energy (excluding wind), and carbon dioxide (CO2) management. Corporate represents the key support functions, comprising holdings and treasury, headquarters, central functions and Shell�� self-insurance activities. In October 2011, the Company bought a marine terminal on Canada's Pacific Coast as a possible site for a liquefied natural gas export terminal. In January 2012, the Company's 50% owned, Australia Arrow Energy Holdings Pty Ltd acquired all of the shares in Bow Energy Ltd. In January 2014, Royal Dutch Shell plc completed the acquisition of Repsol S.A.'s liquefied natural gas (LNG) portfolio outside North America.

Upstream International manages the Upstream businesses outside the Americas. It searches for and recovers crude oil and natural gas, liquefies and transports gas, and operates the upstream and midstream infrastructure necessary to deliver oil and gas to market. Upstream International also manages Shell�� entire liquefied petroleum gas (LNG) business, gas to liquids (GTL) and the wind business in Europe. Its activities are organized primarily within geographical units, although there are some activities that are mana! ged across the businesses or provided through support units.

Upstream Americas manages the Upstream businesses in North and South America. It searches for and recovers crude oil and natural gas, transports gas and operates the upstream and midstream infrastructure necessary to deliver oil and gas to market. Upstream Americas also extracts bitumen from oil sands that is converted into synthetic crude oil. Additionally, it manages the United States-based wind business. It comprises operations organized into business-wide managed activities and supporting activities.

Downstream manages Shell�� manufacturing, distribution and marketing activities for oil products and chemicals. These activities are organized into globally managed classes of business, although some are managed regionally or provided through support units. Manufacturing and supply includes refining, supply and shipping of crude oil. Marketing sells a range of products including fuels, lubricants, bitumen and liquefied petroleum gas (LPG) for home, transport and industrial use. Chemicals produces and markets petrochemicals for industrial customers, including the raw materials for plastics, coatings and detergents. Downstream also trades Shell�� flow of hydrocarbons and other energy-related products, supplies the Downstream businesses, markets gas and power and provides shipping services. Downstream additionally oversees Shell�� interests in alternative energy (including biofuels, and excluding wind) and CO2 management.

Projects and Technology manages the delivery of Shell�� major projects and drives the research and innovation to create technology solutions. It provides technical services and technology capability covering both Upstream and Downstream activities. It is also responsible for providing functional leadership across Shell in the areas of health, safety and environment, and contracting and procurement.

Advisors' Opinion:

• [By WALLSTCHEATSHEET]

  Royal Dutch Shell is an oil and gas company that operates worldwide. The company has just announced a new CEO that is bringing a different vision with him. The stock is trading near lows for the year but a new CEO may be the catalyst that the stock needs. Over the last four quarters, earnings have been mixed while revenue figures have been declining. Relative to its peers and sector, Royal Dutch Shell has been a weak year-to-date performer. WAIT AND SEE what this new CEO does for the company.

• [By WALLSTCHEATSHEET]

  Royal Dutch Shell is focused on oil and gas exploration and distribution, with operations all around the world. The company has agreed to sell a stake in one of its Brazilian offshore assets to Qatar�� state-owned oil and gas company for $1bn. The stock has struggled this year and is currently pulling back. Over the last four quarters, earnings have been decreasing and revenues have been mixed, which has produced conflicting feelings among investors. Relative to its peers and sector, Royal Dutch Shell has been a relative year-to-date performance leader. WAIT AND SEE what Royal Dutch Shell does this quarter.

• [By Jeff Reeves]

  The largest dedicated Europe ETF by assets is the Vanguard FTSE Europe ETF (VGK), with about $13 billion under management. Top holdings include U.K.-based Royal Dutch Shell (RDSA), Swiss consumer products maker Nestle (NSRGY) and HSBC.

• [By Inyoung Hwang]

  BP rallied the most since January 2011 after Europe�� third-largest oil company also increased its dividend. Royal Dutch Shell Plc (RDSA), the region�� biggest crude producer, rose 1.5 percent. Lloyds Banking Group Plc (LLOY) lost 2 percent after reporting that its loss widened in the third quarter.